Human Metapneumovirus (hMPV) is an emerging, highly infectious respiratory pathogen and poses a serious public health threat. Effective management of hospital emergencies associated with hMPV outbreaks requires a multidisciplinary approach. The Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNe) risk approach, originally developed to manage high-impact risk scenarios, provides a framework for dealing with complex public health emergencies. This narrative review explores the application of the CBRNe method in hospital management of hMPV-related emergencies, focusing on three main aspects: prevention, response and mitigation. In the prevention phase, implementation of biosecurity protocols and training of healthcare personnel are key to reducing the risk of Healthcare-Associated Infections (HAIs). The response includes strategies for rapid triage, patient isolation, and the optimal use of hospital resources. Finally, mitigation involves taking measures to limit the impact of the epidemic, such as epidemiological monitoring and inter-institutional coordination. Preliminary results indicate that the CBRNe approach facilitates effective and mitigative management.