Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging cause ofsevere infections in previously healthy children, including rare but life-threatening necrotizing pneumonia.

Case Report: We report the case of a previously healthy 2-month-old male infant who developed necrotizing pneumonia and empyema secondary to CA-MRSA. The clinical course required prolonged intravenous targeted antibiotic therapy and pleural drainage during an extended hospital stay. A household decolonization protocol was implemented upon discharge to prevent recurrence.

Conclusions: This case highlights the capacity of CA-MRSA to cause invasive, severe disease in young infants, even in the absence of classic risk factors. Early recognition of potential MRSA-related infections, timely diagnostic imaging, and prompt initiation of appropriate antimicrobial therapy are critical for improving outcomes.