Toxoplasma gondii is a widespread protozoan parasite capable of infecting nearly all warm-blooded animals, including humans. Although often asymptomatic, infection has been increasingly associated with reproductive complications, particularly in men. Evidence suggests that the parasite may impair male fertility through multiple pathways, including disruption of the blood–testis barrier, direct interaction with sperm, and induction of oxidative stress and inflammatory responses. Hormonal alterations, especially in testosterone regulation, have also been reported, though findings are inconsistent. Clinical and experimental studies further indicate possible effects on semen parameters, including sperm morphology. However, data remain fragmented, and results across populations and models are not always consistent. In addition, currently available therapeutic strategies are not tailored to mitigate reproductive outcomes and may themselves compromise fertility. This review brings together existing findings on the potential links between T. gondii infection and male infertility, while emphasizing that the mechanisms and clinical relevance of these associations are not yet fully understood. Further studies are required to determine causality, define underlying biological pathways, and understand the implications for male reproductive health.