Myasthenic crises can occur spontaneously during myasthenia gravis natural history; they can also be triggered by several factors, such as concomitant infections, pregnancy or drugs. Interferon has been implicated in myasthenic crisis, as well as ribavirin. No data are available about new antiviral drugs for the treatment of hepatitis C virus (DAAs). Here we report the case of a 73-years old man affected by myasthenia gravis and HCV genotype 2a/2c chronic hepatitis, who developed a myasthenic crisis during sofosbuvir and ribavirin treatment. Even if myasthenia gravis is a rare disease, the correlation of myasthenic crises, either direct or indirect, with the use of the new DAAs has to be taken into consideration.
To cite this article
Development of myasthenic crisis during new direct-acting antiviral agents (DAAs) treatment for chronic HCV infection: a case report
Infectious Diseases & Tropical Medicine 2016; 2 (2): e287
Submission date: 08 May 2016
Revised on: 31 May 2016
Accepted on: 24 Jun 2016
Published online: 11 Jul 2016