Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical clinical worsening of a known condition, or the appearance of a new one, after initiating combination antiretroviral treatment (cART) in HIV-infected patients. A young Moroccan man was referred to our hospital after newly diagnosed HIV infection. After ruling out any active opportunistic infection, cART was started, but two weeks later the patient developed high fever unresponsive to medication. With clinical, imaging and laboratory tests, we noticed a rapid dissemination of tuberculosis (TB) with multiple organ involvement. These features were compatible with unmasking TB-IRIS. During hospitalization the patient received the TB treatment with poor improvement.
To cite this article
Rapid development of unmasking disseminated tuberculosis-related immune reconstitution inflammatory syndrome in a young HIV-infected patient after starting combination antiretroviral therapy
Infectious Diseases & Tropical Medicine 2018; 4 (1): e445
Submission date: 10 Mar 2018
Revised on: 12 Mar 2018
Accepted on: 22 Mar 2018
Published online: 26 Mar 2018