Longitudinal bone evaluation in HIV-1 vertically infected patients. A study from childhood to early adult age
Infectious Diseases and Tropical Medicine 2017; 3 (4): e425
Topic: HIV/AIDS
Category: Research article
Abstract
Introduction: The present study aimed at evaluating the role of HIV infection and antiretroviral treatment on bone status through a longitudinal observational study based on a confrontation between two cohorts of HIV-1 vertically infected patients followed from childhood to adulthood.
Materials and Methods: We enrolled all patients with vertical HIV-1 infection who attended our hospital. Every patient was taking cART throughout the observation period. QUS variables AD-SoS and BTT were used to assess bone status. RANKL and OPG measurements were performed during treatment. Height, weight, BMI, pubertal stages and bone age were also determined. Longitudinal trend of HIVRNA and CD4 count and percentage were evaluated. 26 patients have a history of more than one virological failure, 21 patients have at most one virological failure.
Results: 47 patients were studied (23 males). Observations per patient ranged from 3 to 10 (123 observations for females and 122 for males). At baseline, mean age and SD were 10.9±4.6 years in females and 11.3±4.4 years in males. QUS values were reduced in HIV-infected youths, mainly in females. Mean ADSoS and BTT Z-scores were lower in patients with a history of more than one virological failure than in subjects with sustained viral load suppression. ADSoS, but not BTT mean values, were significantly lower in subjects with absolute CD4 lymphocyte count persistently <500 cells/ml than in subjects with CD4 T-lymphocyte count >500 cells/ml. RANKL/OPG ratio, AD-SoS SDS and BTT SDS were not related.
Conclusions: This longitudinal study provides the opportunity to evaluate the effects of HIV vertical infection on bone status. A non-invasive technique like QUS allowed to follow bone mass acquisition during growth.
Materials and Methods: We enrolled all patients with vertical HIV-1 infection who attended our hospital. Every patient was taking cART throughout the observation period. QUS variables AD-SoS and BTT were used to assess bone status. RANKL and OPG measurements were performed during treatment. Height, weight, BMI, pubertal stages and bone age were also determined. Longitudinal trend of HIVRNA and CD4 count and percentage were evaluated. 26 patients have a history of more than one virological failure, 21 patients have at most one virological failure.
Results: 47 patients were studied (23 males). Observations per patient ranged from 3 to 10 (123 observations for females and 122 for males). At baseline, mean age and SD were 10.9±4.6 years in females and 11.3±4.4 years in males. QUS values were reduced in HIV-infected youths, mainly in females. Mean ADSoS and BTT Z-scores were lower in patients with a history of more than one virological failure than in subjects with sustained viral load suppression. ADSoS, but not BTT mean values, were significantly lower in subjects with absolute CD4 lymphocyte count persistently <500 cells/ml than in subjects with CD4 T-lymphocyte count >500 cells/ml. RANKL/OPG ratio, AD-SoS SDS and BTT SDS were not related.
Conclusions: This longitudinal study provides the opportunity to evaluate the effects of HIV vertical infection on bone status. A non-invasive technique like QUS allowed to follow bone mass acquisition during growth.
To cite this article
Longitudinal bone evaluation in HIV-1 vertically infected patients. A study from childhood to early adult age
Infectious Diseases and Tropical Medicine 2017; 3 (4): e425
Publication History
Submission date: 28 Nov 2017
Revised on: 30 Nov 2017
Accepted on: 07 Dec 2017
Published online: 14 Dec 2017
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