Chagas cardiomyopathy, caused by infection with Trypanosoma cruzi, is the leading cause of non-ischemic cardiomyopathy in Latin America. It has been described by the World Health Organization as one of the neglected tropical diseases. This case highlights the importance of including Chagas disease in the differential diagnosis for a patient from an endemic region presenting with non-ischemic cardiomyopathy and characteristic echocardiographic findings of left ventricular apical aneurysm. Treatment with benznidazole or nifurtimox remains controversial, but may be beneficial for selected patients. Our patient completed a sixty-day course of benznidazole provided through the Centers for Disease Control and Prevention.