Chryseobacterium indologenes is a gram-negative bacillus and is an uncommon human pathogen. It is responsible for severe infections such as septicaemia and ventilator-associated pneumonia in immunocompromised patients or after prolonged hospitalization. The pathogenicity and virulence factors of C. indologenes remain unclear. We describe a case of a septic shock in a 77-year-old immunocompetent woman with positive blood culture for Chryseobacterium indologenes, successfully treated with piperacillina/tazobactam. This case indicates that C. indologenes might cause severe disease in immunocompetent persons with otherwise no associated underlying risk factors.