Disease activity Score 28 in patients with Chikungunya virus infection
Infectious Diseases and Tropical Medicine 2022;
8: e794
DOI: 10.32113/idtm_20221_794
Topic: Viral Infection
Category: Original article
Abstract
OBJECTIVE: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya.
PATIENTS AND METHODS: An observational, cross-sectional, descriptive, and analytical study was conducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Activity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression model to determine their influence on patient satisfaction (dependent variable).
RESULTS: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%.
CONCLUSIONS: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions.
PATIENTS AND METHODS: An observational, cross-sectional, descriptive, and analytical study was conducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Activity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression model to determine their influence on patient satisfaction (dependent variable).
RESULTS: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%.
CONCLUSIONS: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions.
To cite this article
Disease activity Score 28 in patients with Chikungunya virus infection
Infectious Diseases and Tropical Medicine 2022;
8: e794
DOI: 10.32113/idtm_20221_794
Publication History
Submission date: 09 Nov 2021
Revised on: 11 Nov 2021
Accepted on: 16 Nov 2021
Published online: 21 Jan 2022
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