Disease activity Score 28 in patients with Chikungunya virus infection
Infectious Diseases & Tropical Medicine 2022;
8: e794
DOI: 10.32113/idtm_20221_794
Topic: Viral Infection
Category: Original article
Abstract
OBJECTIVE: This study aims to evaluate different parameters for determining the inflammatory activity in patients with Chikungunya.
PATIENTS AND METHODS: An observational, cross-sectional, descriptive, and analytical study was conducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Activity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression model to determine their influence on patient satisfaction (dependent variable).
RESULTS: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%.
CONCLUSIONS: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions.
PATIENTS AND METHODS: An observational, cross-sectional, descriptive, and analytical study was conducted with 56 patients from May 2018 to June 2020. Seven independent variables were evaluated [pain in 28 joints, oedema in 28 joints, erythrocyte sedimentation rate, global health assessment, Disease Activity Score 28 (DAS28), pain in 64 joints and oedema in 64 joints] and analysed with a regression model to determine their influence on patient satisfaction (dependent variable).
RESULTS: All studied variables had a significant influence on patient satisfaction, especially the DAS28. However, the agreement between patient satisfaction and the DAS28 was poor (kappa = 0.2). Thus, new cut-off points were established for the DAS28. Compared to the traditional cut-off points used in rheumatoid arthritis, the new cut-off points increased the accuracy of the DAS28 from 37.5% to 51.8%.
CONCLUSIONS: This study contributes to the literature by presenting the DAS28 as a potentially useful instrument in patients with Chikungunya and using cut-off points adjusted for this population. The results can serve as a reference for future studies with larger sample sizes, which would allow more definitive conclusions.
To cite this article
Disease activity Score 28 in patients with Chikungunya virus infection
Infectious Diseases & Tropical Medicine 2022;
8: e794
DOI: 10.32113/idtm_20221_794
Publication History
Submission date: 09 Nov 2021
Revised on: 11 Nov 2021
Accepted on: 16 Nov 2021
Published online: 21 Jan 2022

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